evaluation of preoperative elevation of serum c-reactive protein as an indicator for prognosis in colorectal cancer

نویسندگان

sr mousavi

m talebinfar

m zeinalzadeh

a saberi

چکیده

abstract: background: the c-reactive protein (crp) is a product synthesized in hepatocytes and has been reported to be up-regulated by such proinflammatory cytokines as interleukin-1 (il-1), interleukin-6 (il-6), and tumor necrosis factor (tnf). the significance of a preoperative serum elevation in crp as a predictive indicator for the malignant potential and prognosis in colorectal cancer has not been elucidated. method: forty consecutive patients with colorectal cancer, whose local lesions were resected in our department, plus forty volunteer healthy persons, were selected. any patient with inflammatory diseases such as infection or collagen disease was excluded from the current study. then preoperative serum crp level were measured, and also from the control group. the relationships between the serum elevation of crp and both the clinicopathologic factors and prognosis of the patients was investigated. results: the rate of patients with elevated serum crp level was significantly higher in colorectal cancer patients in comparison with the control group (55% versus 2. 5%). furthermore the incidence of liver metastasis, peritoneal carcinomatosis, histopathologic lymph nodes metastasis, and tumor invasion in colorectal cancer patients with a preoperatively elevated serum crp level were significantly more frequent than in those with a negative serum crp level. the survival rates of colorectal cancer patients without a preoperative elevation of serum crp proved to be significantly more favourable than what in colorectal cancer patients with such an elevation (94. 4% versus 59. 1%; p<0. 001). conclusions: a preoperative serum elevation of crp was thus found to be an indicator of malignant potential of the tumor as well as a predictor for the prognosis of patients with colorectal cancer.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of preoperative elevation of serum c-reactive protein as an indicator for prognosis of colorectal cancer

  Abstract   Background : Cancer has not been elucidated in colerectal site. C-reactive protein   (CRP) is a product synthesized in hepatocytes and has been reported to be up-regulated   by such proinflammatory cytokines as interleukin-1 (IL-1), interleukin-6 (IL-6),   and tumor necrosis factor (TNF). The significance of a preoperative serum elevation   was evaluated using CRP as a predictive i...

متن کامل

evaluation of preoperative elevation of serum c-reactive protein as an indicator for prognosis of colorectal cancer

abstract   background : cancer has not been elucidated in colerectal site. c-reactive protein (crp) is a product synthesized in hepatocytes and has been reported to be up-regulated by such proinflammatory cytokines as interleukin-1 (il-1), interleukin-6 (il-6), and tumor necrosis factor (tnf). the significance of a preoperative serum elevation was evaluated using crp as a predictive indicator f...

متن کامل

Level of C - reactive protein as an indicator for prognosis of premature uterine contractions.

BACKGROUND AND OBJECTIVES high concentrations of maternal C-reactive protein have been associated with adverse pregnancy outcome, and premature uterine contraction may be predicted by elevated levels of C-reactive protein. This may ultimately be simple and cost-effective enough to introduce as a low-risk screening program. PATIENTS AND METHODS an observational case control study was performed...

متن کامل

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...

15 صفحه اول

Preoperative C-Reactive Protein/Albumin Ratio Predicts Prognosis of Patients after Curative Resection for Gastric Cancer

BACKGROUND An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory response markers in patients with gastric cancer (GC). METHODS A retrospective...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of cancer prevention

جلد ۱، شماره ۳، صفحات ۱۲۷-۱۳۰

کلمات کلیدی
[ ' c ' , ' r e a c t i v e p r o t e i n ' , ' c o l o r e c t a l c a n c e r x a 0 r e f e r e n c e s 1 . r e a d j a ' , ' c h o y s t ' , ' b e a l e p j ' , ' e t a l . e v a l u a t i o n o f n u t r i t i o n a l a n d i n f l a m m a t o r y s t a t u s o f a d v a n c e d c o l o r e c t a l c a n c e r p a t i e n t s a n d i t s c o r r e l a t i o n w i t h s u r v i v a l . n u t r c a n c e r . 2 0 0 6 ' , ' 5 5 ( 1 ) ' , 7 8 , ' 8 5 . 2 . p a r k i n d m . g l o b a l c a n c e r s t a t i s t i c s i n t h e y e a r 2 0 0 0 . l a n c e t o n c o l . 2 0 0 1 ' , 2 , 5 3 3 , ' 5 4 3 . 3 . n o z o e t ' , ' s a e k i h ' , ' s u g i m a c h i k . s i g n i f i c a n c e o f p r e o p e r a t i v e e l e v a t i o n o f s e r u m c ' , ' r e a c t i v e p r o t e i n a s a n i n d i c a t o r o f p r o g n o s i s i n e s o p h a g e a l c a r c i n o m a . a m j s u r g . 2 0 0 1 ' , 1 8 2 , 1 9 7 , ' 2 0 1 4 . m i k i s ' , ' i w a n o m ' , ' m i k i y ' , ' e t a l . i n t e r l e u k i n ' , ' 6 f u n c t i o n s a s a n a u t o c r i n e g r o w t h f a c t o r i n r e n a l c e l l c a r c i n o m a . f e b s l e t t . 1 9 8 9 ' , 2 5 0 , 6 0 7 , ' 1 0 . 5 . h a s h i m o t o k ' , ' i k e d a y ' , ' k o r e n a g a d ' , ' e t a l . t h e i m p a c t o f p r e o p e r a t i v e s e r u m c ' , ' r e a c t i v e p r o t e i n o n t h e p r o g n o s i s o f p a t i e n t s w i t h h e p a t o c e l l u l a r c a r c i n o m a . c a n c e r . 2 0 0 5 ' , 1 0 3 , 1 8 5 6 , ' 6 4 6 . g u n t e r m j ' , ' s t o l z e n b e r g ' , ' s o l o m o n r ' , ' c r o s s a j ' , ' e t a l . a p r o s p e c t i v e s t u d y o f s e r u m c ' , ' r e a c t i v e p r o t e i n a n d c o l o r e c t a l c a n c e r r i s k i n m e n . c a n c e r r e s . 2 0 0 6 f e b ' , ' 6 6 ( 4 ) ' , 2 4 8 3 , ' 7 . 7 . r i c h e e ' , ' e t a l . l e v e l s o f p o r t a l a n d s y s t e m i c b l o o d c y t o k i n e s a f t e r c o l e c t o m y i n p a t i e n t s w i t h c a r c i n o m a o r c r o h n & ' , ' # 0 3 9 ' , ' s d i s e a s e . j a m c o l l s u r g . 1 9 9 5 j u n ' , ' 1 8 0 ( 6 ) ' , 7 1 8 , ' 2 4 . 8 . c h u n g y c ' , ' e t a l . s e r u m c ' , ' r e a c t i v e p r o t e i n c o r r e l a t e s w i t h s u r v i v a l i n c o l o r e c t a l c a n c e r p a t i e n t s b u t i s n o t a n i n d e p e n d e n t p r o g n o s t i c i n d i c a t o r . e u r j g a s t r o e n t e r o l h e p a t o l . 2 0 0 3 a p r ' , ' 1 5 ( 4 ) ' , 3 6 9 , ' 7 3 . 9 . n o z o e t ' , ' m a t s u m a t a t ' , ' k i t a m u r a m ' , ' e t a l . s i g n i f i c a n c e o f p r e o p e r a t i v e e l e v a t i o n o f s e r u m c ' , ' r e a c t i v e p r o t e i n a s a n i n d i c a t o r f o r p r o g n o s i s i n c o l o r e c t a l c a n c e r . a m j s u r g . 1 9 9 8 o c t ' , ' 1 7 6 ( 4 ) ' , 3 3 5 , ' 8 . 1 0 . s i m p s o n w g ' , ' h e y s s d ' , ' w h i t i n g p h ' , ' e t a l . a c u t e p h a s e p r o t e i n s a n d r e c o m b i n a n t i l ' , ' 2 t h e r a p y ' , ' p r e d i c t i o n o f r e s p o n s e a n d s u r v i v a l i n p a t i e n t s w i t h c o l o r e c t a l c a n c e r . c l i n e x p i m m u n o l . 1 9 9 5 f e b ' , ' 9 9 ( 2 ) ' , 1 4 3 , ' 7 . . 1 1 . b a l l o u s p ' , ' e t a l . c ' , ' r e a c t i v e p r o t e i n a n d t h e a c u t e p h a s e r e s p o n s e . a d v i n t e r n m e d . 1 9 9 2 ' , 3 7 , 3 1 3 , ' 3 6 . 1 2 . g e w a r z h c ' , ' e t a l . c ' , ' r e a c t i v e p r o t e i n a n d t h e a c u t e p h a s e r e s p o n s e . a d v i n t e r n m e d . 1 9 8 2 ' , 2 7 , 3 4 5 , ' 7 2 . 1 3 . h e l z l s o u e r k j ' , ' e r l i n g e r t p ' , ' p l a t z e a . c ' , ' r e a c t i v e p r o t e i n l e v e l s a n d s u b s e q u e n t c a n c e r o u t c o m e s ' , ' r e s u l t s f r o m a p r o s p e c t i v e c o h o r t s t u d y . e u r j c a n c e r . 2 0 0 6 a p r ' , ' 4 2 ( 6 ) ' , 7 0 4 , ' 7 1 4 . m i k i c ' , ' k o n i s h i n ' , ' o j i m a e ' , ' e t a l . c ' , ' r e a c t i v e p r o t e i n a s a p r o g n o s t i c v a r i a b l e t h a t r e f l e c t s u n c o n t r o l l e d u p r e g u l a t i o n o f t h e i l ' , 1 , ' i l ' , ' 6 n e t w o r k s y s t e m i n c o l o r e c t a l c a r c i n o m a . d i g d i s s c i . 2 0 0 4 j u n ' , ' 4 9 ( 6 ) ' , 9 7 0 , ' 6 . 1 5 . g u i l l e m p ' , ' t r i b o u l e t j p . e l e v a t e d s e r u m l e v e l s o f c r e a c t i v e p r o t e i n a r e i n d i c a t i v e o f a p o o r p r o g n o s i s i n p a t i e n t s w i t h e s o p h a g e a l c a n c e r . d i s e s o p h a g u s . 2 0 0 5 ' , 1 8 , 1 4 6 , ' 1 5 0 . 1 6 . s t a m a t i a d i s a p ' , ' m a n o u r a s a j ' , ' t r i a n t o s g n ' , ' e t a l . c o m b i n a t i o n o f s e r u m c a r c i n o e m b r y o n i c a n t i g e n a n d c r e a c t i v e p r o t e i n a u s e f u l t e s t i n p r e o p e r a t i v e s t a g i n g o f c o l o r e c t a l c a n c e r . e u r j s u r g o n c o l . 1 9 9 2 ' , 1 8 , 4 1 , ' 3 . 1 7 . w e i n s t e i n p s ' , ' s k i n n e r m ' , ' s i p e j d ' , ' e t a l . a c u t e p h a s e p r o t e i n s o r t u m o r m a r k e r s ' , ' t h e r o l e o f s a a ' , ' s a p ' , ' c r p a n d c e a a s i n d i c a t o r s o f m e t a s t a s i s i n a b r o a d s p e c t r u m o f n e o p l a s t i c d i s e a s e . s c a n d j i m m u n o l . 1 9 8 4 ' , 1 9 , 1 9 3 , ' 1 9 . 1 8 . f a l c o n e r j s ' , ' f e a r o n k c ' , ' r o s s j a ' , ' e t a l . a c u t e p h a s e p r o t e i n r e s p o n s e a n d s u r v i v a l i n p a n c r e a t i c c a n c e r . c a n c e r . 1 9 9 5 ' , 7 5 , 2 0 7 7 , ' 8 2 . 1 9 . c a s t e l l j v ' , ' g ó m e z ' , ' l e c h ó n m j ' , ' d a v i d m ' , ' e t a l . a c u t e p h a s e r e s p o n s e o f h u m a n h e p a t o c y t e s ' , ' r e g u l a t i o n o f a c u t e p h a s e p r o t e i n s y n t h e s i s b y i n t e r l e u k i n ' , ' 6 . h e p a t o l . 1 9 9 0 ' , 1 2 , 1 1 7 9 , ' 8 6 . 2 0 . g e l i n j ' , ' m o l d a w e r l l ' , ' l ö n n r o t h c ' , ' e t a l . r o l e o f e n d o g e n o u s t u m o r n e c r o s i s f a c t o r a l p h a a n d i n t e r l e u k i n ' , ' 1 f o r e x p r i m e n t a l t u m o r g r o w t h a n d t h e d e v e l o p m e n t o f c a n c e r c a c h e x i a . c a n c e r r e s . 1 9 9 1 ' , 5 1 , 4 1 5 , ' 2 1 . 2 1 . c o o p e r e h ' , ' e t a l . a c u t e p h a s e r e a c t a n t p r o t e i n s i n c a n c e r . i n ' , ' k l e i n g ' , ' w e i n h o u s e s ' , ' e d s . a d v a n c e s i n c a n c e r r e s e a r c h . 3 0 t h e d . n e w y o r k ' , ' a c a d e m i c p r e s s ' , 1 9 7 9 , 1 , ' 4 4 . 2 2 . s h u m i n m ' , ' e t a l . c ' , ' r e a c t i v e p r o t e i n l e v e l s a r e n o t a s s o c i a t e d w i t h i n c r e a s e d r i s k f o r c o l o r e c t a l c a n c e r i n w o m e n . a n n i n t e r n m e d . 2 0 0 5 m a r 1 5 ' , ' 1 4 2 ( 6 ) ' , 4 2 5 , ' 3 2 . 2 3 . c h u n g y c ' , ' c h a n g y f . s e r u m i n t e r l e u k i n ' , ' 6 l e v e l s r e f l e c t t h e d i s e a s e s t a t u s o f c o l o r e c t a l c a n c e r . j s u r g o n c o l . 2 0 0 3 ' , 8 3 , 2 2 2 , ' 6 . 2 4 . k i n o s h i t a t ' , ' i t o h ' , ' m i k i c . s e r u m i n t e r l e u k i n ' , ' 6 l e v e l r e f l e c t s t h e t u m o r p r o l i f e r a t i v e a c t i v i t y i n p a t i e n t s w i t h c o l o r e c t a l c a r c i n o m a . c a n c e r . 1 9 9 9 ' , 8 5 , 2 5 2 6 , ' 3 1 . 2 5 . y u c e y a r s ' , ' e r t ü r k s ' , ' d i r i c a n a ' , ' e t a l . t h e r o l e o f a c u t e ' , ' p h a s e r e a c t a n t p r o t e i n s ' , ' c a r c i n o e m b r y o n i c a n t i g e n a n d c a 1 9 ' , ' 9 a s a m a r k e r i n t h e p r e o p e r a t i v e s t a g i n g o f c o l o r e c t a l c a n c e r ' , ' a p r o s p e c t i v e c l i n i c a l s t u d y . i n t s u r g . 1 9 9 6 a p r ' , ' j u n ' , ' 8 1 ( 2 ) ' , 1 3 6 , ' 9 . ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023